8-Bromoguanosine-13C2,15N

8-Bromoguanosine-13C2,15N is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033) . 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function[1][2][3].

Product Specifications

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Others

Smiles

O[C@H]1[C@H]([C@@H](O[C@@H]1CO)N2[13C](N=C(N3)N)=[13C]([15N]=C2Br)C3=O)O

Molecular Formula

C8 13C2H12BrN4 15NO5

Molecular Weight

365.12

References & Citations

[1]Goodman MG, Weigle WO. Intracellular lymphocyte activation and carrier-mediated transport of C8-substituted guanine ribonucleosides. Proc Natl Acad Sci U S A. 1984 Feb;81 (3) :862-6.|[2]Koo GC, Jewell ME, Manyak CL, Sigal NH, Wicker LS. Activation of murine natural killer cells and macrophages by 8-bromoguanosine. J Immunol. 1988 May 1;140 (9) :3249-52.|[3]Yajima R, et al. A conformationally restricted guanosine analog reveals the catalytic relevance of three structures of an RNA enzyme. Chem Biol. 2007 Jan;14 (1) :23-30.