Diclofenac Amide-13C6

Diclofenac Amide-13C6 is the 13C-labeled Diclofenac amide (HY-134521) . Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037) . Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX) . Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474) -induced rat paw edema model without causing gastric ulcer (300 μmol/kg) [1].

Product Specifications

UNSPSC

12352005

Target

COX; Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C1C[13C]2=[13C]([13C]([H])=[13C]([13C]([H])=[13C]2N1C3=C(C=CC=C3Cl)Cl)[H])[H]

Molecular Formula

C8 13C6H9Cl2NO

Molecular Weight

284.09

References & Citations

[1]Santos JL, et al., Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. Int J Mol Sci. 2012 Nov 19;13 (11) :15305-20.