TAN-420E
TAN-420E (Dihydroherbimycin A) is an antibiotic, that can be isolated from the fermentation product of Streptomyces hygroscopicus. TAN-420E exhibits cytotoxicity in cancer cells P-388 and KB. TAN-420E scavenges DPPH free radicals with an IC50 of 1.3 μM[1][2].
Product Specifications
CAS Number
91700-93-5
Product Name Alternative
Dihydroherbimycin A
UNSPSC
12352005
Target
Antibiotic; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Infection
Smiles
C[C@H]1C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(C)\C(NC2=C(O)C([C@@H]1OC)=CC(O)=C2)=O
Molecular Formula
C30H44N2O9
Molecular Weight
576.68
References & Citations
[1]Lin LZ, et al., 1H-nmr analysis of herbimycins and dihydro-herbimycins. J Nat Prod. 1988 Nov-Dec;51 (6) :1161-5|[2]Chang HB, et al., Antioxidant properties of dihydroherbimycin A from a newly isolated Streptomyces sp. Biotechnol Lett. 2007 Apr;29 (4) :599-603.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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