TAN-420E

TAN-420E (Dihydroherbimycin A) is an antibiotic, that can be isolated from the fermentation product of Streptomyces hygroscopicus. TAN-420E exhibits cytotoxicity in cancer cells P-388 and KB. TAN-420E scavenges DPPH free radicals with an IC50 of 1.3 μM[1][2].

Product Specifications

CAS Number

[91700-93-5]

Product Name Alternative

Dihydroherbimycin A

UNSPSC

12352005

Target

Antibiotic; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Infection

Smiles

C[C@H]1C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(C)\C(NC2=C(O)C([C@@H]1OC)=CC(O)=C2)=O

Molecular Formula

C30H44N2O9

Molecular Weight

576.68

References & Citations

[1]Lin LZ, et al., 1H-nmr analysis of herbimycins and dihydro-herbimycins. J Nat Prod. 1988 Nov-Dec;51 (6) :1161-5|[2]Chang HB, et al., Antioxidant properties of dihydroherbimycin A from a newly isolated Streptomyces sp. Biotechnol Lett. 2007 Apr;29 (4) :599-603.