L-2-Hydroxyglutaric acid-d5 (disodium)

L-2-Hydroxyglutaric acid-d5 disodium ((2S) -2-Hydroxyglutaric acid-d5 disodium) is the deuterium labeled L-2-Hydroxyglutaric acid disodium (HY-W015114) . L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

Product Specifications

Product Name Alternative

(2S) -2-Hydroxyglutaric acid-d5 (disodium)

UNSPSC

12352211

Target

Endogenous Metabolite; Histone Demethylase; Isotope-Labeled Compounds; Mitochondrial Metabolism

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=C(O[Na])C([2H])(C([2H])([C@](O)(C(O[Na])=O)[2H])[2H])[2H]

Molecular Formula

C5HD5Na2O5

Molecular Weight

197.11

References & Citations

[1]Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4 (11) :1290-8.|[2]da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21 (4) :217-24.