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TDHL-d10

TDHL-d10 (Tergurid-d10; Terguride-d10; trans-Dihydrolisuride-d10) is the deuterium labeled TDHL (HY-12714) . TDHL (Tergurid) is a dopamine receptor agonist with a Kd of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.

Product Specifications

Product Name Alternative

Tergurid-d10; Terguride-d10; trans-Dihydrolisuride-d10

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

O=C(N[C@@H]1CN([C@]([H])(CC2=CNC3=C2C4=CC=C3)[C@@]4(C1)[H])C)N(C([2H])(C([2H])([2H])[2H])[2H])C([2H])(C([2H])([2H])[2H])[2H]

Molecular Formula

C20H18D10N4O

Molecular Weight

350.52

References & Citations

[1]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340 (2) :369-76.|[2]Mizokawa T, et al. Terguride as a new anti-hyperprolactinemic agent: characterization in rats and dogs in comparison with bromocriptine. Jpn J Pharmacol. 1993 Nov;63 (3) :269-78.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-W744750/

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Curated Selection

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