2-Hydroxy Imiquimod
2-Hydroxy Imiquimod (R-842), a hydroxylated metabolite of Imiquimod , is an immunomodulating agent. 2-Hydroxy Imiquimod can induce IFN-α, TNF-α, IL-1, IL-6 and IL-8 in human blood cells. 2-Hydroxy Imiquimod exhibits antivirus and antitumor activities. 2-Hydroxy Imiquimod can be used for the researches of cancer, infection and immunology[1][2].
Product Specifications
CAS Number
112668-45-8
Product Name Alternative
R-842
UNSPSC
12352005
Target
Drug Metabolite; IFNAR; Interleukin Related; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Smiles
OC(C)(CN1C=NC2=C1C3=C(C=CC=C3)N=C2N)C
Molecular Formula
C14H16N4O
Molecular Weight
256.30
References & Citations
[1]Weeks CE, et al. Induction of interferon and other cytokines by imiquimod and its hydroxylated metabolite R-842 in human blood cells in vitro. J Interferon Res. 1994 Apr;14 (2) :81-5.|[2]Imbertson LM, et al. Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463. J Invest Dermatol. 1998 May;110 (5) :734-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; IL-8
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