Sulindac Sulfone-d6

Sulindac Sulfone-d6 is the deuterium labeled Sulindac sulfone (HY-B1787) . Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. Sulindac sulfone inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is used in cancer research[1].

Product Specifications

CAS Number

[2519512-94-6]

UNSPSC

12352005

Target

Drug Metabolite; Isotope-Labeled Compounds; mTOR

Related Pathways

Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

FC1=CC=C2C(C(C([2H])(C(O)=O)[2H])=C(/C2=C(C3=CC=C(C=C3)S(=O)(C([2H])([2H])[2H])=O)\[2H])C)=C1

Molecular Formula

C20H11D6FO4S

Molecular Weight

378.45

References & Citations

[1]Aono Y, et al. Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2. Biochem Biophys Res Commun. 2018 Nov 10;505 (4) :1203-1210.