5-Hydroxy saxagliptin (hydrochloride)

5-Hydroxy saxagliptin hydrochloride is an active metabolite of Saxagliptin (HY-10285) and a potent and selective DPP-4 inhibitor. 5-Hydroxy saxagliptin hydrochloride has Ki values of 2.6 nM and 2.9 nM for humans and cynomolgus monkeys, respectively. 5-Hydroxy saxagliptin hydrochloride can be used in the research of type 2 diabetes mellitus[1].

Product Specifications

UNSPSC

12352005

Target

Dipeptidyl Peptidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O[C@@]1(C2)C[C@@]3([C@@H](C(N4[C@H](C#N)C[C@H]5[C@@H]4C5)=O)N)C[C@@](C[C@@H]2C3)(O)C1.Cl

Molecular Formula

C18H26ClN3O3

Molecular Weight

367.87

References & Citations

[1]Wang A, et al. Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor. BMC Pharmacol. 2012 Apr 4;12:2.