(R) -Colchicine
(R) -Colchicine is the R-isomer of Colchicine. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID) -induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research[1][2][3][4][5].
Product Specifications
CAS Number
75520-89-7
UNSPSC
12352005
Target
Apoptosis; Autophagy; Drug Isomer; Microtubule/Tubulin; NOD-like Receptor (NLR)
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology
Smiles
COC1=C2C(C([C@@H](CCC2=CC(OC)=C1OC)NC(C)=O)=C3)=CC=C(OC)C3=O
Molecular Formula
C22H25NO6
Molecular Weight
399.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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