N-Desmethyl rosuvastatin (disodium hydrate)

N-Desmethyl rosuvastatin disodium hydrate is an active metabolite of HMG-CoA reductase (HMGCR) inhibitor rosuvastatin (HY-17504) . N-Desmethyl rosuvastatin disodium hydrate can be utilized in research of rosuvastatin metabolism[1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Drug Metabolite; HMG-CoA Reductase (HMGCR)

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease; Cardiovascular Disease

Smiles

O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C([N-]S(=O)(C)=O)N=C1C2=CC=C(F)C=C2.[Na+].O

Molecular Formula

C21H26FN3Na2O7S

Molecular Weight

529.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Bai X, et al. Rosuvastatin, Rosuvastatin-5 S-lactone, and N-desmethyl Rosuvastatin in Human Plasma by UPLC-MS/MS and Its Application to Clinical Study. Drug Res (Stuttg) . 2018 Jun;68 (6) :328-334.