18-Hydroxy-11-deoxy corticosterone

18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields[1].

Product Specifications

CAS Number

[379-68-0]

Product Name Alternative

18-OH-DOC; 11-Deoxy-18-hydroxycorticosterone

UNSPSC

12352211

Target

Angiotensin Receptor; Drug Metabolite; Melanocortin Receptor; Mineralocorticoid Receptor

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

OC[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1

Molecular Formula

C21H30O4

Molecular Weight

346.46

References & Citations

[1]Braley LM, et al. The effect of angiotensin II and saralasin on 18-hydroxy-11-deoxycorticosterone production by isolated human adrenal glomerulosa cells. J Clin Endocrinol Metab. 1979 Oct;49 (4) :600-3.|[2]Carroll J, et al. The relationship between plasma 18-hydroxy-11-deoxycorticosterone levels and production of hypertension in the rat. J Steroid Biochem. 1981 Oct;14 (10) :989-95.|[3]Müller J. The conversion of 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone to aldosterone by rat adrenal tissue: evidence for an alternative biosynthetic pathway. J Steroid Biochem. 1980 Mar;13 (3) :245-51.|[4]Slominski A, et al. Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells. FEBS Lett. 1999 Jul 23;455 (3) :364-6.|[5]Giesbertz P, et al. Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes. Diabetologia. 2015 Sep;58 (9) :2133-43.