18-Hydroxy-11-deoxy corticosterone
18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields[1].
Product Specifications
CAS Number
379-68-0
Product Name Alternative
18-OH-DOC; 11-Deoxy-18-hydroxycorticosterone
UNSPSC
12352211
Target
Angiotensin Receptor; Drug Metabolite; Melanocortin Receptor; Mineralocorticoid Receptor
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
OC[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
Molecular Formula
C21H30O4
Molecular Weight
346.46
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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