CRBN ligand-187
CRBN ligand-187 is a CRBN-type E3 ubiquitin ligase ligand that can be used for synthesis of TQ-3959 (HY-175541) [1].
Product Specifications
CAS Number
[2883704-28-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
NC1=CC2=C(C=C1)C(C3CCC(NC3=O)=O)=NO2
Molecular Formula
C12H11N3O3
Molecular Weight
245.23
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Ren J, et al. Discovery of TQ-3959 as a Potent and Orally Bioavailable BTK PROTAC Degrader Incorporating a Novel Benzisoxazole-Based CRBN Ligand for the Treatment of B-Cell Malignancies. J Med Chem. 2025 Aug 14;68 (15) :15960-15979.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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