Ethyl tosylcarbamate-d7
Ethyl tosylcarbamate-d7 is the deuterium labeled Ethyl tosylcarbamate. Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].
Product Specifications
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Metabolic Disease
Smiles
[2H]C1=C(C([2H])=C(C(S(NC(OCC)=O)(=O)=O)=C1[2H])[2H])C([2H])([2H])[2H]
Molecular Formula
C10H6D7NO4S
Molecular Weight
250.32
References & Citations
[1]Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27 (4) :301-27.|[2]Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57 (13), 1476–1478.|[3]Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55 (6) : p. 722-30.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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