LCC-12 (formate)
LCC-12 (formate) is a copper (II) chelator and a derivative of the biguanide metformin (HY-B0627) . LCC-12 (formate) reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+. LCC-12 (formate) reduces IL-1β, IL-2, IL-6, IL-8, and TNF-α levels, as well as JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4) levels in primary human cytokine-activated monocyte-derived macrophages (MDMs) . LCC-12 (formate) reduces the number of CD80+ and CD86+ cytokine-activated MDMs. LCC-12 LCC-12 (formate) improves survival in a mouse model of sepsis induced by LPS or cecal ligation and puncture[1].
Product Specifications
UNSPSC
12352211
Target
Interleukin Related; IRAK; JAK; NADH Dehydrogenase; STAT; TNF Receptor
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Purity
99.9
Smiles
NC(NC(NCCCCCCCCCCCCNC(NC(N)=N)=N)=N)=N.O=CO
Molecular Formula
C17H38N10O2
Molecular Weight
414.55
References & Citations
[1]Solier S, et al. A druggable copper-signalling pathway that drives inflammation. Nature. 2023 May;617 (7960) :386-394.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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