Dehydro nicardipine

Dehydro nicardipine is a dihydropyridine metabolite of Nicardipine (HY-12515) and belongs to the dihydropyridine class of compounds. Dehydro nicardipine can selectively inhibit the aggregation of Aβ monomers, specifically regulate the extension and binding of Aβ soluble aggregates, change the morphology of Aβ aggregates, and inhibit the growth of aggregate length. Dehydro nicardipine can be used in the study of Alzheimer's disease (AD) [1].

Product Specifications

CAS Number

[59875-58-0]

UNSPSC

12352005

Target

Amyloid-β

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1=C(C2=CC=CC([N+]([O-])=O)=C2)C(C(OCCN(C)CC3=CC=CC=C3)=O)=C(C)N=C1C)OC

Molecular Formula

C26H27N3O6

Molecular Weight

477.51

References & Citations

[1]Tseng J H. Discovery and Characterization of Multi-Target Directed Ligands as Inhibitors of Amyloid-β Aggregation and Regulators of Alzheimer's Disease[J]. 2014.