Dehydro nicardipine
Dehydro nicardipine is a dihydropyridine metabolite of Nicardipine and belongs to the dihydropyridine class of compounds. Dehydro nicardipine can selectively inhibit the aggregation of Aβ monomers, specifically regulate the extension and binding of Aβ soluble aggregates, change the morphology of Aβ aggregates, and inhibit the growth of aggregate length. Dehydro nicardipine can be used in the study of Alzheimer's disease (AD).
Product Specifications
CAS Number
59875-58-0
UNSPSC
12352005
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=C(C2=CC=CC([N+]([O-])=O)=C2)C(C(OCCN(C)CC3=CC=CC=C3)=O)=C(C)N=C1C)OC
Molecular Formula
C26H27N3O6
Molecular Weight
477.51
References & Citations
[1]Tseng J H. Discovery and Characterization of Multi-Target Directed Ligands as Inhibitors of Amyloid-β Aggregation and Regulators of Alzheimer's Disease[J]. 2014.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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