Rhetsinine
Rhetsinine is an aldose reductase inhibitor isolated from Evodia rutaecarpa, exhibiting an IC50 value of 24.1 μM. At a concentration of 100 μM, rhetsinine significantly inhibits sorbitol accumulation by 79.3%. This compound shows potential for research in diabetic complications, including diabetic neuropathy and retinopathy[1].
Product Specifications
CAS Number
[526-43-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Aldose Reductase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C(N1C(C2=C(CC1)C3=C(C=CC=C3)N2)=O)C4=C(NC)C=CC=C4
Molecular Formula
C19H17N3O2
Molecular Weight
319.36
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kato A, et al. Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity. Phytomedicine. 2009 Mar;16 (2-3) :258-61.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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