VU0469650 (hydrochloride)

VU0469650 hydrochloride is a brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) . VU0469650 hydrochloride inhibits glutamate-induced calcium flux in cells expressing human mGluR1 (IC50= 99 nM) . VU0469650 hydrochloride is promising for research of central nervous system diseases such as anxiety, addiction, and epilepsy[1].

Product Specifications

UNSPSC

12352005

Target

MGluR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(N1[C@@H](CN(C2=C(N=CC=C2)C#N)CC1)C)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3.Cl

Molecular Formula

C22H29ClN4O

Molecular Weight

400.94

References & Citations

[1]Lovell KM, et al. N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett. 2013 Jul 1;23 (13) :3713-8.