Moroxydine (hydrochloride) -d8

Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A) . Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV) . Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].

Product Specifications

CAS Number

[2469734-82-3]

Product Name Alternative

ABOB hydrochloride-d8

UNSPSC

12352005

Target

Apoptosis; Caspase; HCV; HSV; Influenza Virus; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

N=C(N1C([2H])(C([2H])(OC([2H])(C1([2H])[2H])[2H])[2H])[2H])NC(N)=N.Cl

Molecular Formula

C6H6D8ClN5O

Molecular Weight

215.71

References & Citations

[1]Yu XB, et al. Moroxydine (ABOB) hydrochloride hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul;131:156-65. |[2]Yu XB, et al. In vitro antiviral efficacy of Moroxydine (ABOB) hydrochloride hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus. Dis Aquat Organ. 2016 Oct 27;121 (3) :189-199. |[3]Yu XB, et al. Effects of Moroxydine (ABOB) hydrochloride hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation. Res Vet Sci. 2018 Apr;117:37-44.