2-Ethylhexyl (E) -3- (4- (methoxy-d3) phenyl) acrylate
2-Ethylhexyl (E) -3- (4- (methoxy-d3) phenyl) acrylate is the deuterium labeled Octinoxate (HY-B1234) . Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo[1][2][3][4][5].
Product Specifications
CAS Number
[2734919-82-3]
UNSPSC
12352005
Target
Androgen Receptor; Cytochrome P450; Estrogen Receptor/ERR; Isotope-Labeled Compounds; Thyroid Hormone Receptor
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Smiles
CCCCC(COC(/C=C/C1=CC=C(C=C1)OC([2H])([2H])[2H])=O)CC
Molecular Formula
C18H23D3O3
Molecular Weight
293.42
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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