Picolinafen
Picolinafen is a pyridine-class herbicide that acts as a phytoene desaturase (PDS) inhibitor. Picolinafen effectively controls broadleaf weeds and disrupts carotenoid biosynthesis. Picolinafen exhibits cytotoxicity to porcine trophectoderm (pTr) and luminal epithelial (pLE) cells. Picolinafen induces (ROS accumulation, calcium depletion, and activates (MAPK and PI3K signaling pathways, leading to decreased cell viability, increased apoptosis, impaired migration, and altered expression of implantation-related genes. Picolinafen has an LD50 value of 2.7 mg/kg in mammals and 7 μg/L in fish. Picolinafen exhibits toxic effects during zebrafish embryogenesis[1][2].
Product Specifications
CAS Number
137641-05-5
Product Name Alternative
AC 900001
UNSPSC
12352005
Hazard Statement
H410
Target
Apoptosis; Calcium Channel; Cytochrome P450; p38 MAPK; PI3K; Reactive Oxygen Species (ROS)
Related Pathways
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=NC(OC2=CC(C(F)(F)F)=CC=C2)=CC=C1)NC3=CC=C(C=C3)F
Molecular Formula
C19H12F4N2O2
Molecular Weight
376.30
Precautions
P273-P391-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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