Regorafenib N-oxide and N-desmethyl (M5) -d3-1
Regorafenib N-oxide and N-desmethyl (M5) -d3-1 (N-Desmethyl regorafenib N-oxide-d3-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4[1].
Product Specifications
Product Name Alternative
N-Desmethyl regorafenib N-oxide-d3-1
UNSPSC
12352005
Target
C-Kit; Drug Metabolite; Isotope-Labeled Compounds; Raf; VEGFR
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)NC2=C(F)C([2H])=C(OC3=CC=N(C(C(N)=O)=C3)=O)C([2H])=C2[2H]
Molecular Formula
C20H10D3ClF4N4O4
Molecular Weight
487.81
References & Citations
[1]Ying-Hui Li, et al. Functional characterization of 27 CYP3A4 protein variants to metabolize regorafenib in vitro. Basic Clin Pharmacol Toxicol. 2019 Oct;125 (4) :337-344.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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