Panaxytriol

Panaxytriol is an active component of ginseng. Panaxytriol inhibits the nuclear translocation of NF-κB, thereby reducing the production of pro-inflammatory factors (such as TNF-α, IL-1β, IL-6) and nitric oxide (NO) induced by LPS (HY-D1056) . Panaxytriol upregulates CYP3A4 by activating the nuclear receptor PXR/CAR. Panaxytriol improves motor dysfunction in a mouse model of brain inflammation. Panaxytriol can be used in the research of neurodegenerative diseases (such as Alzheimer's disease) [1][2].

Product Specifications

CAS Number

[87005-03-6]

UNSPSC

12352211

Target

Constitutive Androstane Receptor; Cytochrome P450; Interleukin Related; NF-κB; Pregnane X Receptor (PXR) ; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CCCCCCC[C@@H](O)[C@H](O)CC#CC#C[C@H](O)C=C

Molecular Formula

C17H26O3

Molecular Weight

278.39

References & Citations

[1]Yan J, et al. Panaxytriol upregulates CYP3A4 expression through the interaction between nuclear regulators and DNA response elements. J Ethnopharmacol. 2023 Jun 28;310:116398.|[2]Hiramatsu G, et al. Panaxytriol Inhibits Lipopolysaccharide-Induced Microglia Activation in Brain Inflammation in Vivo. Biol Pharm Bull. 2021;44 (7) :1024-1028.