Lumichrome-d8
Lumichrome-d8 is the deuterium labeled Lumichrome. Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway[1][2].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; ERK; Isotope-Labeled Compounds; MDM-2/p53; NF-κB; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(N1)C2=NC3=C(C(C([2H])([2H])[2H])=C(C([2H])=C3N=C2NC1=O)C([2H])([2H])[2H])[2H]
Molecular Formula
C12H2D8N4O2
Molecular Weight
250.28
References & Citations
[1]Bergh VJ, et al. Influence of formulation on photoinactivation of bacteria by lumichrome. Pharmazie. 2015;70 (9) :574-580. |[2]Chantarawong W, et al. Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism. Nutr Cancer. 2019;71 (8) :1390-1402. |[3]Liu C, et al., Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL-induced NFAT activation and calcium signaling. J Cell Physiol. 2018 Nov;233 (11) :8971-8983.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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T-complex Protein 1 theta (T-complex Protein 1 theta Subunit, TCP1 theta, TCP1-theta, TCP-1 theta, Chaperonin Containing TCP1 theta, Chaperonin-containing TCP-1 theta, CCT theta, CCT-theta, CCTQ, Chaperonin Containing TCP1 Subunit 8, Chaperonin-containing TCP-1 Subunit 8, CCT8, Chaperonin Containing TCP1 Subunit 8 theta, Chaperonin-containing TCP-1 Subunit 8 theta, Chromosome 21 Open Reading Frame 112, C21orf112, D21S246, KIAA0002, PRED71, Renal Carcinoma Antigen NY-REN-15) (FITC) discontinued
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