Norfenfluramine (hydrochloride)

Norfenfluramine hydrochloride ((±) -Norfenfluramine hydrochloride) is the primary metabolite of Fenfluramine, formed through N-dealkylation of Fenfluramine. Norfenfluramine hydrochloride is also a potent anorexiant. Norfenfluramine hydrochloride can regulate serotonergic neurotransmission. In addition, Norfenfluramine hydrochloride exhibits sedative effects after acute administration[1][2].

Product Specifications

CAS Number

[673-18-7]

Product Name Alternative

(±) -Norfenfluramine (hydrochloride)

UNSPSC

12352005

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

NC(CC1=CC=CC(C(F)(F)F)=C1)C.Cl

Molecular Formula

C10H13ClF3N

Molecular Weight

239.67

References & Citations

[1]Martin P, et al. In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions. Pharmacol Res Perspect. 2022 Jun;10 (3) :e00958.|[2]Goudie AJ, et al. Chronic anorexic and behavioural effects of the fenfluramine metabolite, norfenfluramine: an evaluation of its role in the actions of fenfluramine. Psychopharmacologia. 1974;38 (1) :67-74.|[3]Rothman RB, Clark RD, Partilla JS, Baumann MH. (+) -Fenfluramine and its major metabolite, (+) -norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003;305 (3) :1191-1199.|[4]Erenburg N, Hamed R, Shaul C, Perucca E, Bialer M. Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain. Epilepsia. 2023;64 (6) :1673-1683.