RepSox (hydrochloride)

RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5) . RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.

Product Specifications

CAS Number

[2319939-07-4]

Product Name Alternative

E-616452 (hydrochloride) ; SJN 2511 (hydrochloride)

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; TGF-beta/Smad

Related Pathways

Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

CC1=NC(C2=NNC=C2C3=CC=C4N=CC=CC4=N3)=CC=C1.Cl

Molecular Formula

C17H14ClN5

Molecular Weight

323.78

References & Citations

[1]Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47 (18) :4494-506.