Ro 20-0657/000-d3

Ro 20-0657/000-d3 is the deuterium labeled Ro 20-0657/000 (HY-100622) . Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine[1][2][3].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

OC(C1=C(N)N=C(N)N=C1)C2=CC(OC)=C(OC([2H])([2H])[2H])C(OC)=C2

Molecular Formula

C14H15D3N4O4

Molecular Weight

309.34

References & Citations

[1]Robert E. London, et al. Nuclear magnetic resonance study of interaction of ligands with Streptococcus faecium dihydrofolate reductase labeled with [.gamma.-13C]tryptophan. Biochemistry 1982, 21, 18, 4450-4458.|[2]van 't Klooster GA, et al. Determination of trimethoprim and its oxidative metabolites in cell culture media and microsomal incubation mixtures by high-performance liquid chromatography. J Chromatogr. 1992 Sep 2;579 (2) :354-60.|[3]Tadić Đ, et al. Simultaneous determination of multiclass antibiotics and their metabolites in four types of field-grown vegetables. Anal Bioanal Chem. 2019 Aug;411 (20) :5209-5222.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported