N-Deschlorobenzoyl indomethacin-d3

N-Deschlorobenzoyl indomethacin-d3 is the deuterium labeled N-Deschlorobenzoyl indomethacin (HY-W008567) . N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity[1].

Product Specifications

CAS Number

[3029090-15-8]

UNSPSC

12352005

Target

Drug Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Smiles

CC(NC1=C2C=C(OC([2H])([2H])[2H])C=C1)=C2CC(O)=O

Molecular Formula

C12H10D3NO3

Molecular Weight

222.26

References & Citations

[1]Liedtke AJ, et al. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J Med Chem. 2013 Mar 28;56 (6) :2429-46.