N-Deschlorobenzoyl indomethacin-d3
N-Deschlorobenzoyl indomethacin-d3 is the deuterium labeled N-Deschlorobenzoyl indomethacin. N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity[1].
Product Specifications
CAS Number
3029090-15-8
UNSPSC
12352005
Target
Drug Metabolite; Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Others
Smiles
CC(NC1=C2C=C(OC([2H])([2H])[2H])C=C1)=C2CC(O)=O
Molecular Formula
C12H10D3NO3
Molecular Weight
222.26
References & Citations
[1]Liedtke AJ, et al. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J Med Chem. 2013 Mar 28;56 (6) :2429-46.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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