T-1032

T-1032 is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 1.0 nM. T-1032 shows relaxant effect on isolated rabbit corpus cavernosum. T-1032 can be used for the research of erectile dysfunction[1].

Product Specifications

CAS Number

212500-03-3

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Endocrinology

Smiles

OS(O)(=O)=O.NC1=CC=C(N2C(C(OC)=O)=C(C3=CC(OC)=C(C(OC)=C3)OC)C4=C(C=C(C=C4)OCC5=NC=CC=C5)C2=O)C=C1

Molecular Formula

C32H31N3O11S

Molecular Weight

665.67

References & Citations

[1]Ukita T, et al. Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives. J Med Chem. 2001 Jun 21;44 (13) :2204-18.