T-1032
T-1032 is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 1.0 nM. T-1032 shows relaxant effect on isolated rabbit corpus cavernosum. T-1032 can be used for the research of erectile dysfunction[1].
Product Specifications
CAS Number
212500-03-3
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology
Smiles
OS(O)(=O)=O.NC1=CC=C(N2C(C(OC)=O)=C(C3=CC(OC)=C(C(OC)=C3)OC)C4=C(C=C(C=C4)OCC5=NC=CC=C5)C2=O)C=C1
Molecular Formula
C32H31N3O11S
Molecular Weight
665.67
References & Citations
[1]Ukita T, et al. Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives. J Med Chem. 2001 Jun 21;44 (13) :2204-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE5
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