NIP 142

NIP-142 is a benzopyran derivative with multiple ion channel-blocking effects. NIP-142 selectively blocks the potassium ion channels enriched in atrial muscle, prolonging the effective refractory period (ERP) and action potential duration (APD) of the atrium, while having minimal effect on ventricular repolarization. NIP-142 also inhibits L-type/T-type calcium channels and sodium channels, further contributing to its anti-arrhythmic effect. NIP-142 shows significant efficacy in various atrial fibrillation models. NIP-142 can be used for research on arrhythmias[1].

Product Specifications

CAS Number

[203002-58-8]

UNSPSC

12352005

Target

Calcium Channel; Potassium Channel; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

COC(C=C1)=CC=C1CC(NC2=C([N+]([O-])=O)C=C(OC(C)([C@@H]3O)C)C([C@@H]3NC4CC4)=C2)=O

Molecular Formula

C23H27N3O6

Molecular Weight

441.48

References & Citations

[1]Tanaka H, Hashimoto N. A multiple ion channel blocker, NIP-142, for the treatment of atrial fibrillation. Cardiovasc Drug Rev. 2007 Winter;25 (4) :342-56.