Rimeporide-15N3 (hydrochloride)

Rimeporide-15N3 (hydrochloride) (EMD-87580-15N3 (hydrochloride) ) is 15N labeled Rimeporide hydrochloride. Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1) .

Product Specifications

Product Name Alternative

EMD-87580-15N3 (hydrochloride)

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Na+/H+ Exchanger (NHE)

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O=S(C1=C(C=C(C(C([15NH]C([15NH2])=[15NH])=O)=C1)C)S(=O)(C)=O)(C)=O.Cl

Molecular Formula

C11H16Cl 15N3O5S2

Molecular Weight

372.83

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.