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Z-Doxepin-d3 (Hydrochloride)

Z-Doxepin-d3 hydrochloride is the deuterium labeled 7-Hydroxychlorpromazine hydrochloride. 7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine hydrochloride can increase prolactin levels in rats. 7-Hydroxychlorpromazine hydrochloride can increase dopamine turnover and has a sedative effect. In addition, 7-Hydroxychlorpromazine hydrochloride can effectively inhibit amphetamine-induced stereotyped behavior in rats and is used in the study of psychosis[1][2].

Product Specifications

CAS Number

2469242-68-8

UNSPSC

12352005

Target

Dopamine Receptor; Drug Metabolite; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

ClC(C=C1)=CC2=C1SC(C=C(O)C=C3)=C3N2CCCN(C([2H])([2H])[2H])C([2H])([2H])[2H].Cl

Molecular Formula

C17H14D6Cl2N2OS

Molecular Weight

377.36

References & Citations

[1]Meltzer H Y, et al. Effect of metabolites of chlorpromazine on plasma prolactin levels in male rats[J]. European Journal of Pharmacology, 1977, 41 (4) : 431-436.|[2]Perry T L, et al. 7-Hydroxychlorpromazine: potential toxic drug metabolite in psychiatric patients[J]. Science, 1964, 146 (3640) : 81-83.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

Phase 2

Frequently Asked Questions

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