Diphenyltin Dichloride-d10
Diphenyltin Dichloride-d10 is the deuterium labeled NSC405640 (HY-144105) . NSC405640 is a potent inhibitor of the MDM2-p53 interaction. NSC405640 rescues structural p53 mutations. NSC405640 selectively inhibits the growth of cell lines with wild-type p53[1].
Product Specifications
UNSPSC
12352005
Target
Isotope-Labeled Compounds; MDM-2/p53
Related Pathways
Apoptosis; Others
Field of Research
Cancer
Smiles
Cl[Sn](Cl)(C1=C(C([2H])=C(C([2H])=C1[2H])[2H])[2H])C2=C(C([2H])=C(C([2H])=C2[2H])[2H])[2H]
Molecular Formula
C12D10Cl2Sn
Molecular Weight
353.89
References & Citations
[1]Chen S, et al. Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. Cancer Cell. 2021;39 (2) :225-239.e8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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