D-myo-Inositol-1,4,5,6-tetraphosphate (tetrasodium)

D-myo-Inositol-1,4,5,6-tetraphosphate tetrasodium (D-Ins (1,4,5,6) P4 tetrasodium) is one of several different inositol oligophosphate isomers implicated in signal transduction. It almost completely inhibits calcium-activated chloride channels at a concentration of 8-10 μM [1].

Product Specifications

Product Name Alternative

Inositol 1,4,5,6-tetraphosphate (tetrasodium) ; D-Ins (1,4,5,6) P4 (tetrasodium)

UNSPSC

12352211

Target

Chloride Channel; Drug Isomer

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Metabolic Disease

Smiles

O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@H]1O)OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O

Molecular Formula

C6H12Na4O18P4

Molecular Weight

588.00

References & Citations

[1]Yang X, et al. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. J Biol Chem. 1999 Jul 2;274 (27) :18973-80.|[2]Xie W, et al. Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase II-activated chloride conductance in T84 colonic epithelial cells. J Biol Chem. 1996 Jun 14;271 (24) :14092-7.