Nicotinamide N-oxide-d4

Nicotinamide N-oxide-d4 is the deuterium labeled Nicotinamide N-oxide (HY-101407) . Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

Product Specifications

CAS Number

[1246817-64-0]

UNSPSC

12352005

Target

CXCR; Drug Metabolite; Endogenous Metabolite; Isotope-Labeled Compounds; Oxidative Phosphorylation

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=C([2H])[N+]([O-])=C([2H])C([2H])=C1[2H])N

Molecular Formula

C6H2D4N2O2

Molecular Weight

142.15

References & Citations

[1]Real AM, et al. Nicotinamide N-oxidation by CYP2E1 in human liver microsomes. Drug Metab Dispos. 2013 Mar;41 (3) :550-3.|[2]Cutshall NS, et al. Nicotinamide N-oxides as CXCR2 antagonists. Bioorg Med Chem Lett. 2001 Jul 23;11 (14) :1951-4.