(S) - (-) -Felodipine

(S) - (-) -Felodipine is a S-enantiomer of Felodipine. (S) - (-) -Felodipine is an antihypertensive agent. Felodipine is a 1,4-dihydropyridine derivative and a vasoselective calcium antagonist. Felodipine can prevent the activation of the vascular effector cells and interfere with the contractile process in vitro. Felodipine lowers mean arterial blood pressure by 20% in dog model. (S) - (-) -Felodipine shows high metabolic rate in rat and dog liver microsomes[1][2].

Product Specifications

CAS Number

[105618-03-9]

UNSPSC

12352005

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

CCOC(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=C(C(Cl)=CC=C2)Cl)=O

Molecular Formula

C18H19Cl2NO4

Molecular Weight

384.25

References & Citations

[1]Eriksson, U. G., et al., (1991) . Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human. Drug metabolism and disposition: the biological fate of chemicals, 19 (5), 889-894. |[2]Ljung, B. Vascular Selectivity of Felodipine. Drugs 29 (Suppl 2), 46-58 (1985) .