Dimebutic acid-d6

Dimebutic acid-d6 (NSC-16045-d6; NSC-741804-d6) is the deuterium labeled Dimebutic acid (HY-W015881) . Dimebutic acid is a fatty acid derivative. Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal globin production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid is used in the study of β-thalassemia and sickle cell disease[1][2][3].

Product Specifications

CAS Number

[101419-75-4]

Product Name Alternative

NSC-16045-d6; NSC-741804-d6

UNSPSC

12352211

Target

Bcl-2 Family; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Smiles

OC(C(C([2H])([2H])[2H])(CC)C([2H])([2H])[2H])=O

Molecular Formula

C6H6D6O2

Molecular Weight

122.20

References & Citations

[1]Dr Susan P. Perrine MD, et al. Evaluation of Safety and Pharmacokinetics of Sodium 2,2 Dimethylbutyrate, a Novel Short Chain Fatty Acid Derivative, in a Phase 1, Double-Blind, Placebo-Controlled, Single-Dose, and Repeat-Dose Studies in Healthy Volunteers.Clinical Pharmacology Volume51, Issue8 August 2011 Pages 1186-1194|[2]Parise RA, et al. Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862 (1-2) :168-74.|[3]Terse PS, et al. Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats. Toxicol Pathol. 2011 Jun;39 (4) :614-22.