Chlorido[N, N'-disalicylidene-1,2-phenylenediamine]iron (III)

Chlorido[N, N'-disalicylidene-1,2-phenylenediamine]iron (III) generates lipid-based ROS and induce ferroptosis

Product Specifications

CAS Number

[39916-28-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ferroptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

[Cl-][Fe+3]123[O-]C4=C(C=[N]1C5=C([N]2=CC6=C([O-]3)C=CC=C6)C=CC=C5)C=CC=C4

Molecular Formula

C20H14ClFeN2O2

Molecular Weight

405.64

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jessica Sagasser, et al. A New Approach in Cancer Treatment: Discovery of Chlorido[ N, N'-disalicylidene-1,2-phenylenediamine]iron (III) Complexes as Ferroptosis Inducers. J Med Chem. 2019 Sep 12;62 (17) :8053-8061.|[2]Soo-Young Lee, et al. [FeIII (salophene) Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells. Leukemia Research 35 (2011) 387-393.