Succinate (calcium)

Succinate calcium is a key intermediate product of the citric acid cycle (tricarboxylic acid cycle) . Succinate calcium can act as a specific ligand for the G protein-coupled receptor GPR91. Succinate calcium can increase the amplitude of calcium transient in cardiac muscle cells and accelerate the decay rate of calcium transient. Succinate calcium can induce myocardial apoptosis[1].

Product Specifications

CAS Number

[140-99-8]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Orphan GPCR

Related Pathways

Apoptosis; GPCR/G Protein

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Smiles

O=C([O-])CCC([O-])=O.[Ca+2]

Molecular Formula

C4H4CaO4

Molecular Weight

156.15

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Aguiar C J, et al. Gomes E R M, et al. Succinate modulates Ca2+ transient and cardiomyocyte viability through PKA-dependent pathway[J]. Cell calcium, 2010, 47 (1) : 37-46.