(R, S, S) -Dihydrotetrabenazine

(R, S, S) -Dihydrotetrabenazine (R, S, S-DHTBZ) is a kind of discrete isomeric secondary alcohol metabolites of Tetrabenazine (TBZ, HY-B0590), is a poor VMAT2 inhibitor (Ki = 690 nM) [1].

Product Specifications

CAS Number

[924854-62-6]

Product Name Alternative

R, S, S-DHTBZ

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; Monoamine Transporter

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Purity

98.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H][C@@]12C[C@H]([C@H](CN1CCC3=C2C=C(C(OC)=C3)OC)CC(C)C)O

Molecular Formula

C19H29NO3

Molecular Weight

319.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Dimitri E Grigoriadis, et al. Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites. J Pharmacol Exp Ther. 2017 Jun;361 (3) :454-461.