(R, S, S) -Dihydrotetrabenazine
(R, S, S) -Dihydrotetrabenazine (R, S, S-DHTBZ) is a kind of discrete isomeric secondary alcohol metabolites of Tetrabenazine (TBZ, HY-B0590), is a poor VMAT2 inhibitor (Ki = 690 nM).
Product Specifications
CAS Number
924854-62-6
Product Name Alternative
R, S, S-DHTBZ
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite; Monoamine Transporter
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Purity
98.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H][C@@]12C[C@H]([C@H](CN1CCC3=C2C=C(C(OC)=C3)OC)CC(C)C)O
Molecular Formula
C19H29NO3
Molecular Weight
319.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Dimitri E Grigoriadis, et al. Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites. J Pharmacol Exp Ther. 2017 Jun;361 (3) :454-461.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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