(S) -Thalidomide-4-OH

(S) -Thalidomide-4-OH is the S-isomer of Thalidomide-4-OH (HY-103596) . Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs[1].

Product Specifications

CAS Number

[2357105-36-1]

UNSPSC

12352005

Hazard Statement

H302, H361

Target

Drug Isomer

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.0

Smiles

OC1=C2C(N(C(C2=CC=C1)=O)[C@H]3CCC(NC3=O)=O)=O

Molecular Formula

C13H10N2O5

Molecular Weight

274.23

Precautions

H302, H361

References & Citations

[1]Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25 (5) :597-604.