5- (2-Chloroacetamide) thalidomide
5- (2-Chloroacetamide) thalidomide is a Thalidomide analogue. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. This structure features a chloroacetamide, which is a thiol-specific reactive group.
Product Specifications
CAS Number
1957235-51-6
UNSPSC
12352005
Hazard Statement
H302, H314
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
95.0
Smiles
ClCC(NC1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O)=O
Molecular Formula
C15H12ClN3O5
Molecular Weight
349.73
Precautions
H302, H314
References & Citations
[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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