Norketotifen
Norketotifen is the active metabolite of Ketotifen (HY-B0157) . Norketotifen exhibits skin anti-inflammatory activity, anti-malarial activity, and antipruritic activity against non-histamine-mediated dog itching in mice. Norketotifen effectively inhibits TNF-α release without causing any sedative side effects. Norketotifen can be used for research on non-sedating anti-inflammatory agents[1].
Product Specifications
CAS Number
[34580-20-6]
UNSPSC
12352005
Hazard Statement
H301
Target
Drug Metabolite; Parasite; TNF Receptor
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C1C2=C(/C(C3=C(C1)C=CC=C3)=C4CCNCC\4)C=CS2
Molecular Formula
C18H17NOS
Molecular Weight
295.40
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Aberg AKG, et al. Ketotifen is a Prodrug. Norketotifen is the active metabolite. Drug Dev Res. 2022 Apr;83 (2) :362-367.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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