Quinolinic acid-13C3, 15N

Quinolinic acid-13C3, 15N (2,3-Pyridinedicarboxylic Acid-13C3, 15N) is the 13C- and 15N-labeled Quinolinic acid (HY-100807) . Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].

Product Specifications

CAS Number

[2377475-84-6]

Product Name Alternative

2,3-Pyridinedicarboxylic Acid-13C3, 15N

UNSPSC

12352005

Target

Endogenous Metabolite; iGluR; Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=[13CH][13CH]=[13CH][15N]=C1C(O)=O)O

Molecular Formula

C4 13C3H5 15NO4

Molecular Weight

171.09

References & Citations

[1]Jang S, et al. Neuroprotective effects of (-) -epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Res. 2010 Feb 8;1313:25-33.|[2]Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 (Pt 5) :1249-73.