D-α-Hydroxyglutaric acid-d5 (disodium)
D-α-Hydroxyglutaric acid-d5 disodium (Disodium (R) -2-hydroxyglutarate-d5) is the deuterium labeled D-α-Hydroxyglutaric acid disodium. D-α-Hydroxyglutaric acid disodium (Disodium (R) -2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].
Product Specifications
Product Name Alternative
Disodium (R) -2-hydroxyglutarate-d5
UNSPSC
12352211
Target
Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Purity
98.14
Smiles
O=C(O[Na])C([2H])(C([2H])([C@@](O)(C(O[Na])=O)[2H])[2H])[2H]
Molecular Formula
C5HD5Na2O5
Molecular Weight
197.11
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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