Cortodoxone-d7

Cortodoxone-d7 (11-Deoxycortisol-d7) is a deuterium labeled Cortodoxone (HY-77839) . Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation[1][2].

Product Specifications

Product Name Alternative

11-Deoxycortisol-d7; Cortexolone-d7; Reichstein's substance S-d7

UNSPSC

12352211

Target

Endogenous Metabolite; Glucocorticoid Receptor; Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Inflammation/Immunology

Smiles

OC([2H])(C([C@@]1([C@]2(CC[C@]3([C@@]([H])(CC([2H])(C4=C(C(C([2H])(C[C@@]43C)[2H])=O)[2H])[2H])[C@@]2(CC1)[H])[H])C)O)=O)[2H]

Molecular Formula

C21H23D7O4

Molecular Weight

353.50

References & Citations

[1]Gjerde H, et al. 11-Deoxycortisol induces hepatic tryptophan oxygenase in rats. Acta Pharmacol Toxicol (Copenh) . 1985 Jul;57 (1) :36-9. |[2]Peng C, et al. 11-deoxycortisol positively correlates with T cell immune traits in physiological conditions. EBioMedicine. 2024 Jan;99:104935.