Chlortetracycline-13C, d3 (hydrochloride)

Chlortetracycline-13C, d3 hydrochloride (7-Chlorotetracycline-13C, d3 hydrochloride) is the 13C- and deuterium labeled Chlortetracycline hydrochloride (HY-B1327) . Chlortetracycline hydrochloride is an orally active, selective antibiotic, that inhibits methanogenic bacteria through inhibition of bacterial protein synthesis. Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, that inhibits binding of aminoacyl-tRNA to ribosomes[1][2][3][4][5].

Product Specifications

Product Name Alternative

7-Chlorotetracycline-13C, d3 (hydrochloride)

UNSPSC

12352005

Target

Antibiotic; Bacterial; Isotope-Labeled Compounds; Parasite

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

O=C(N)C(C1=O)=C([C@H]([C@@]2(C[C@@]3([C@](O)(C4=C(C(O)=CC=C4Cl)C(C3=C([C@@]21O)O)=O)C)[H])[H])N(C)[13C]([2H])([2H])[2H])O.Cl

Molecular Formula

C21 13CH21D3Cl2N2O8

Molecular Weight

519.35

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Elmund GK, et al. Role of excreted chlortetracycline in modifying the decomposition process in feedlot waste. Bull Environ Contam Toxicol. 1971 Mar-Apr;6 (2) :129-32.|[3]Saling PM, et al. Mouse gamete interactions during fertilization in vitro. Chlortetracycline as a fluorescent probe for the mouse sperm acrosome reaction. J Cell Biol. 1979 Dec;83 (3) :544-55.|[4]Reyes-Contreras C, et al. Methanogenic toxicity evaluation of chlortetracycline hydrochloride[J]. Electronic Journal of Biotechnology, 2015, 18 (6) : 445-450.|[5]Liu D, et al. Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability[J]. Acta Pharm. 2020 Dec 1;70 (4) :483-498.