Dopamine D2 receptor antagonist-3
Dopamine D2 receptor antagonist-3 (Example 17) is an orally active and selective dopamine D2 receptor antagonist with a pIC50 of 5.52. Dopamine D2 receptor antagonist-3 exhibits antipsychotic activity in the Apomorphine (HY-12723) induced agitation in rats. Dopamine D2 receptor antagonist-3 can be used for psychiatric and neurological disorders research[1].
Product Specifications
CAS Number
[1032714-06-9]
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
FC1=CC(CN2CCC(NC3=NN=C(C#N)C=C3)CC2)=CC(C(F)(F)F)=C1
Molecular Formula
C18H17F4N5
Molecular Weight
379.35
References & Citations
[1]Gregor James MacDonal, et al. Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists. US8466153. 2013-06-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS4516629-01 20 Tests
Anti-Human CD49d Monoclonal Antibody (PE/Cyanine5.5 Conjugated)
Ask
View Details MBS4516629-02 50 Tests
Anti-Human CD49d Monoclonal Antibody (PE/Cyanine5.5 Conjugated)
Ask
View Details MBS4516629-03 100 Tests
Anti-Human CD49d Monoclonal Antibody (PE/Cyanine5.5 Conjugated)
Ask
View Details MBS4516629-04 5x 100 Tests
Anti-Human CD49d Monoclonal Antibody (PE/Cyanine5.5 Conjugated)
Ask
View Details 