ELP-004

ELP-004 is a TRPC channel inhibitor and inhibtis TRPC channel-mediated Ca2+ entry. ELP-004 is an osteoclast inhibitor and inhibits osteoclast differentiation. ELP-004 inhibits basal Ca2+ and related NFATc1 translocation in inflammatory osteoclastogenesis. ELP-004 reduces bone erosion in a mouse model of rheumatoid arthritis[1][2].

Product Specifications

CAS Number

[15533-81-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Inflammation/Immunology

Concentration

10mM

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCC(N(C1=CC(Cl)=C(C=C1)Cl)C)=O

Molecular Formula

C10H11Cl2NO

Molecular Weight

232.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Ray S, et al. Targeting TRPC channels for control of arthritis-induced bone erosion. Sci Adv. 2025 Jan 17;11 (3) :eabm9843.|[2]McCall JL, et al. Preclinical evaluation of ELP-004 in mice. Pharmacol Res Perspect. 2024 Aug;12 (4) :e1230.